Product

Bioreactor & fermenter for research
and development

SMB
(Simulated Moving Bed)
– BIOCNS S

BIOCNS S is an advanced SMB chromatography system enabling continuous, high-purity separation for biotech, fine chemical, sugar, and pharmaceutical applications.
SMB is a continuous separation process that precisely controls feed, desorbent, extract, and raffinate flows, overcoming the limitations of batch chromatography.
This process reduces solvent consumption by up to 50% and boosts productivity by 3 times, enabling cost-effective, high-efficiency purification at scale.

Features
  • Easy and fast continuous separation and purification process
  • Flexibility in selecting the number and type of columns
  • Patented valve block minimizing dead volume (Multifunction Valve)
  • Integration with various detectors and real-time monitoring
  • Support for operation method optimization programs
  • Stepwise scale-up from Lab → Pilot → Production
  • Process cost reduction through solvent reuse
  • Configurable as closed loop or open loop

BIOCNS S Series Product Code Classification

Why SMB?

Recognized as an efficient, cost-effective alternative to conventional batch chromatography

SMB is a next-generation continuous separation and purification technology applicable across various industries.

Especially Delivers high recovery, low solvent use, and shorter process times in large-scale production.
As a result, SMB is widely utilized across the biotechnology, pharmaceutical, and food industries.

Pilot-scale SMB
(Simulated Moving Bed) Chromatography for L-ribose Purification

Pilot-scale validation with BIOCNS-SP achieved stable high purity and yield in L-ribose purification.
The data compare simulation and experimental results, confirming the reproducibility and design reliability of BIOCNS-SP.

Performance Data – BIOCNS-SP (Pilot-scale SMB)

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Parameters L-ribose L-arabinose
Simulation Experiment Simulation Experiment
Purity (%) 99.35 98.04 98.57 93.48
Yield (%) 98.48 92.55 99.40 98.30
Enrichment (%) 53.34 44.80 71.66 65.97
Productivity (kg/L adsorbent/day) 0.30 – 0.43 –
D/F (-) 2.2 – – –

Comparison of SMB vs Batch Chromatography

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Item SMB System Batch Chromatography
Process type Continuous Discontinuous
Solvent consumption Reduced by 2–5 times through solvent recycling High solvent consumption
Productivity (g Feed/day/L column) 189.9 1.99
Buffer consumption (mL Buffer/g Feed) 723 18
Product concentration High concentration, easy solvent removal Low concentration, requires additional concentration step

※ Source: Ganapathy Subramanian, Bioseparation and Bioprocessing (WILEY-VCH), p.236

Technical Specifications

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Specification BIOCNS-SL (Lab) BIOCNS-SP (Pilot)
Number of Columns 4–8 4–16
Column Diameter (mm) 6.6–25 25–500
Flow Rate (mL/min) 0.1–100 1-1000
Pressure (PSI) 0–100 / 0–1000 0–500
Operating Temp (°C) 20–80
Pump Type Dual piston
Flow Accuracy ±5 %
Valve System Manifold system block
Column Material Glass / STS316L STS316L
Detector UV (190–1000 nm), optional RI / Cond / pH / Brix
Control System HMI + PLC
Operation Mode Step / Sequence Step / Sequence Control (Automatic switching)
Monitoring Real-time (UV, Cond, pH)
Productivity (kg/day) 0.6–1.0 3.0–5.0

※ Industrial-scale SMB systems are available with customizable columns, flow rates, and automation levels.

Applications

  • Separation and purification of rare sugars (e.g., L-ribose, L-arabinose)
  • Production of pharmaceutical intermediates and active compounds
  • Purification of food-grade and fine chemical raw materials
  • Continuous bioprocessing and process optimization research
  • Support for pilot- and industrial-scale process validation

Available Options

  • Customizable column number and size (4–16 columns, 6–500 mm)
  • Automatic valve switching and flow balancing system
  • Integration with multiple detectors (UV, RI, PDA, pH, Brix, etc.)
  • Data logging and trend analysis module
  • SCADA-based remote process control functionality

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