CNS

UF System
(Ultrafiltration System)
– BIOCNS U

UF System BIOCNS U is a compact ultrafiltration system for R&D and small-scale production, supporting MF, DF, and UF processes.
Through precise control and data-based process monitoring, it provides high recovery rates and stable separation efficiency.

Features

Supports microfiltration, diafiltration, and ultrafiltration processes
Various sensors and control options (OD, pH, conductivity, load cell, flowmeter, etc.)
Compatible with major membrane brands (Sartorius, Millipore, PALL)
Intuitive control based on automatic pressure control valves and a HMI touch panel
Provides highly reliable quality and maintenance services
Automatic control based on PF, ΔP, TMP, flux, and end-stop control
Data acquisition and visualization program optimized for concentration, desalting, and buffer exchange processes

BIOCNS U Series Product Code Classification

Key Components

Component	Description
BIOCNS UL / UP	equipment for laboratory and small-scale production
HMI (Touch)	Built-in automatic control and data visualization program
Automatic pressure control valve	Automates flow rate and TMP control
Membrane holders compatible with major three brands	Sartorius, Millipore, PALL
Various sensor modules	pH, conductivity, pressure, flow, load cell
Data logging and analysis functions	Real-time recording and display of TMP, flux, and concentration changes

Performance evaluation results of BIOCNS U under various process conditions

Performance

Concentration : Feed flow rate 10 L/min, TMP 1.5 bar
Buffer exchange : Feed flow rate 7 L/min, TMP 1.0 bar
Diafiltration : Feed flow rate 9 L/min, TMP 1.5 bar

Results

9.2-fold concentration (19 minutes required)
Average flux: 48 LMH
Final antibody concentration: 15.5 g/L
Recovery rate: 93.9%

Specification

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Specification	Lab (BIOCNS UL)	Pilot (BIOCNS UP)
Type	Benchtop	Standing
Reservoir Type	Glass vessel (Non-jacket)	Tank (Non-jacket / Jacket)
Reservoir Volume (L)	1.3 – 1.5	5 - 50
Pressure Sensor	Diaphragm (0 – 2 bar)	Diaphragm (0 – 5 bar)
Temperature Sensor	Probe (0 – 70 °C ± 0.2 °C)
Conductivity Sensor	Probe (0 – 100 mS/cm)
Flow Meter	Ultrasonic (0 – 5 L/min)	Ultrasonic (0 – 15 L/min)
Pressure Control Valve	Diaphragm or Pinch (0 – 3 bar)	Diaphragm (0 – 3 bar)
Operating Temperature (°C)	RT	RT (Chiller / Water bath optional)
CIP	Manual (cleaning port)	Automatic (option)
Control Panel	PC	PC + HMI touch display
Software	Integrated HMI Program
Controller	PLC + PID feedback control

Applications

Purification and concentration of biopharmaceuticals such as antibody proteins, enzymes, and peptides
Filtration and desalting of cell culture media, fermentation broths, and protein solutions
Separation and purification processes in the food and fine chemical industries
Pilot-scale UF process development and scale-up studies
Membrane performance comparison and process condition optimization experiments

Available Options

Custom-designed membrane holders (compatible with third-party modules)
Temperature-controlled jacket tank (jacket-type reservoir)
Automatic CIP cleaning module
Real-time data logging and integrated report output
Control system compliant with GMP and 21 CFR Part 11

System Highlights

Real-time monitoring of TMP, flux, ΔP, and PF
Automatic end-stop and safety interlock functions
Support for calibration of various sensors
PC-based automatic process control and data backup
Remote monitoring and service support

Product